Spontaneous reactivation of mouse plasma cholinesterase after inhibition by various organophosphorus compounds.
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منابع مشابه
The reactivation of cholinesterase inhibited with organophosphorus compounds. 2. Reactivation by pyridinealdoxime methiodides.
Material8 The pyridinealdoxime methiodides were obtained by boiling the oximes with methyl iodide in ethanol (Green & Saville, 1956). Quinoline-4-aldoxime methiodide, m.p. 232-233° (Found: I 40x2. C11H11N20I requires 1 40.4%) and pyridine-2-alidoxime ethiodide, m.p. 186-188° (Found: I 45-3. C8H11N20I requires I 45-6%) were prepared similarly. Reactivation experiments These were carried out on h...
متن کاملThe kinetics of reactivation, by oximes, of cholinesterase inhibited by organophosphorus compounds.
The inhibition of cholinesterase (ChE) and related enzymes, by organophosphorus compounds, is generally believed to occur by direct phosphorylation of some group at the active centre of the enzyme, together with the liberation of an acid anion (Wilson, 1951; Balls & Jansen, 1952; Hartley & Kilby, 1952; Aldridge, 1954; Kilby & Youatt, 1954). Inhibition by organophosphorus compounds is generally ...
متن کاملThe differentiation of true and pseudo cholinesterase by organophosphorus compounds.
1. Five preparations of testicular hyaluronidase, one of streptococcal and one of staphylococcal origin were compared by an accurate skin-diffuiion assay and by viscosimetric and turbidimetric methods. 2. With testicular preparations the results of the three methods agree well, provided that the potency is measured in terms ofa reference preparation of enzyme, and that the pH and ionic strength...
متن کاملReturn of cholinesterase activity in the rat after inhibition by organophosphorus compounds. 2. A comparative study of true and pseudo cholinesterase.
Hulme, A. C. & Arthington, W. (1950). Nature, Lond., 165, 716. Jelliffe, D. B. & Stuart, K. L. (1954). Brit. med. J. 9 January, p. 75. Jordan, E. 0. & Burrows, W. (1937). Amer. J. Hyg. 25 (3), 520. Lynch, S. J., Larson, E. & Doughty, D. D. (1951). Proc. Fla hort. Soc. 64, 281. Moore, S. & Stein, W. H. (1948). J. biol. Chem. 176, 367. Patrick, S. J. (1954). Amer. J. appl. Physiol. 7, 140. Scott,...
متن کاملThe inhibition of hydrolytic enzymes by organophosphorus compounds.
It has been shown that several hydrolytic enzymes with different specificities undergo similar reactions with diisopropyl phosphorofluoridate (1) and other related toxic organophosphorus compounds (2). These conclusions were based on kinetic studies, particularly the influence of pH on the rates of reaction, and on inhibition characteristics. Reactions of this type have provided a unique method...
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ژورنال
عنوان ژورنال: Journal of Pharmacobio-Dynamics
سال: 1984
ISSN: 0386-846X,1881-1353
DOI: 10.1248/bpb1978.7.322